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Graphical contents list • CONTENTS LIST PDF (536 K) | |||
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Synthesis of a novel tetrahydroisoquinolino[2,1-c][1,4]benzodiazepine ring system with DNA recognition potential • SHORT COMMUNICATION Kiran Kumar Kothakonda and D. Subhas Bose SummaryPlus | Full Text + Links | PDF (254 K) | |||
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Discovery of potent and orally bioavailable N,N′-diarylurea antagonists for the CXCR2 chemokine receptor • SHORT COMMUNICATION Qi Jin, Hong Nie, Brent W. McCleland, Katherine L. Widdowson, Michael R. Palovich, John D. Elliott, Richard M. Goodman, Miriam Burman, Henry M. Sarau, Keith W. Ward et al. SummaryPlus | Full Text + Links | PDF (263 K) | |||
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Synthesis, receptor binding and functional studies of mesoridazine stereoisomers • SHORT COMMUNICATION Sungwoon Choi, Deborah Haggart, Lawrence Toll and Gregory D. Cuny SummaryPlus | Full Text + Links | PDF (279 K) | |||
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A library synthesis of 4-hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic acid ethyl ester derivatives as anti-tumor agents • SHORT COMMUNICATION Ichiro Hayakawa, Rieko Shioya, Toshinori Agatsuma, Hidehiko Furukawa, Shunji Naruto and Yuichi Sugano SummaryPlus | Full Text + Links | PDF (282 K) | |||
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Synthesis of an unusual branched-chain sugar, 5-C-methyl-L-idopyranose for SAR studies of pyranmycins: implication for the future design of aminoglycoside antibiotics • SHORT COMMUNICATION Jinhua Wang, Jie Li, Przemyslaw G. Czyryca, Huiwen Chang, Jeff Kao and Cheng-Wei Tom Chang SummaryPlus | Full Text + Links | PDF (353 K) | |||
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Identification of CJC-1131-albumin bioconjugate as a stable and bioactive GLP-1(7–36) analog • SHORT COMMUNICATION Roger Léger, Karen Thibaudeau, Martin Robitaille, Omar Quraishi, Pieter van Wyk, Nathalie Bousquet-Gagnon, Julie Carette, Jean-Paul Castaigne and Dominique P. Bridon SummaryPlus | Full Text + Links | PDF (288 K) | |||
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Stereoselective synthesis and preliminary evaluation of new D-3-heteroarylcarbonylalanines as ligands of the NMDA receptor • SHORT COMMUNICATION Paulo G. Lima, Rodrigo R.B. Caruso, Simone O. Alves, Renata F. Pessôa, Dayde L. Mendonça-Silva, Ricardo J. Nunes, François Noël, Newton G. Castro and Paulo R.R. Costa SummaryPlus | Full Text + Links | PDF (286 K) | |||
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Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents • SHORT COMMUNICATION Tuan P. Tran, Edmund L. Ellsworth, Michael A. Stier, John M. Domagala, H.D. Hollis Showalter, Stephen J. Gracheck, Martin A. Shapiro, Themis E. Joannides and Rajeshwar Singh SummaryPlus | Full Text + Links | PDF (267 K) | |||
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Nonpeptide αvβ3 antagonists. Part 9: Improved pharmacokinetic profile through the use of an aliphatic, des-amide backbone • SHORT COMMUNICATION David B. Whitman, Ben C. Askew, Le T. Duong, Carmen Fernandez-Metzler, Wasyl Halczenko, George D. Hartman, John H. Hutchinson, Chih-Tai Leu, Thomayant Prueksaritanont, Gideon A. Rodan et al. SummaryPlus | Full Text + Links | PDF (256 K) | |||
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Structure–activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor • SHORT COMMUNICATION Joseph Pontillo, Joseph A. Tran, Melissa Arellano, Beth A. Fleck, Rajesh Huntley, Dragan Marinkovic, Marion Lanier, Jodie Nelson, Jessica Parker, John Saunders et al. SummaryPlus | Full Text + Links | PDF (293 K) | |||
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Structure–activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity • SHORT COMMUNICATION Yoko Nagumo, Hideaki Kakeya, Junichiro Yamaguchi, Takao Uno, Mitsuru Shoji, Yujiro Hayashi and Hiroyuki Osada SummaryPlus | Full Text + Links | PDF (302 K) | |||
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Synthesis of 2′,5′-oligoadenylate analogs containing an adenine acyclonucleoside and their ability to activate human RNase L • SHORT COMMUNICATION Yoshihito Ueno, Shinji Ishihara, Yasutomo Ito and Yukio Kitade SummaryPlus | Full Text + Links | PDF (310 K) | |||
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Synthesis and cellular uptake of a fluorescently labeled cyclic PNA-based compound • SHORT COMMUNICATION Sergio Caldarelli, Geoffrey Depecker, Nadia Patino, Audrey Di Giorgio, Thibault Barouillet, Alain Doglio and Roger Condom SummaryPlus | Full Text + Links | PDF (302 K) | |||
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Design, synthesis and antimalarial activity of a glyoxylylhydrazone library • SHORT COMMUNICATION A. Ryckebusch, J.-S. Fruchart, L. Cattiaux, P. Rousselot-Paillet, V. Leroux, O. Melnyk, P. Grellier, E. Mouray, C. Sergheraert and P. Melnyk SummaryPlus | Full Text + Links | PDF (274 K) | |||
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Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target • SHORT COMMUNICATION Fredik Lehmann, Saba Haile, Eva Axen, Carmen Medina, Jonas Uppenberg, Stefan Svensson, Thomas Lundbäck, Lena Rondahl and Tjeerd Barf SummaryPlus | Full Text + Links | PDF (308 K) | |||
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Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors • SHORT COMMUNICATION Rune Ringom, Eva Axen, Jonas Uppenberg, Thomas Lundbäck, Lena Rondahl and Tjeerd Barf SummaryPlus | Full Text + Links | PDF (361 K) | |||
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Synthesis and structure–activity relationship of a novel sulfone series of TNF-α converting enzyme inhibitors • SHORT COMMUNICATION Chu-Biao Xue, Xiao-Tao Chen, Xiaohua He, John Roderick, Ronald L. Corbett, Bahman Ghavimi, Rui-Qin Liu, Maryanne B. Covington, Mingxin Qian, Maria D. Ribadeneira et al. SummaryPlus | Full Text + Links | PDF (309 K) | |||
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Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents • SHORT COMMUNICATION Jin Hee Ahn, Hye-Min Kim, Sun Ho Jung, Seung Kyu Kang, Kwang Rok Kim, Sang Dal Rhee, Sung-Don Yang, Hyae Gyeong Cheon and Sung Soo Kim Abstract | PDF (270 K) | |||
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Ligand conformation has a definitive effect on 5-HT1A and serotonin reuptake affinity • SHORT COMMUNICATION Kenneth M. Boy, Michael Dee, Joseph Yevich, John Torrente, Qi Gao, Lawrence Iben, Arlene Stark and Ronald J. Mattson SummaryPlus | Full Text + Links | PDF (262 K) | |||
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Synthesis of chiral phosphoantigens and their activity in γδ T cell stimulation • SHORT COMMUNICATION Yongcheng Song, Yonghui Zhang, Hong Wang, Amy Raker, John Sanders, Erin Broderick, Allen Clark, Craig Morita and Eric Oldfield SummaryPlus | Full Text + Links | PDF (374 K) | |||
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4-Aryl-3-(mercapto)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle • SHORT COMMUNICATION Piyasena Hewawasam, Wenhong Fan, Deborah A. Cook, Kimberly S. Newberry, Christopher G. Boissard, Valentin K. Gribkoff, John Starrett and Nicholas J. Lodge SummaryPlus | Full Text + Links | PDF (275 K) | |||
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Anti-HIV activity of some synthetic lignanolides and intermediates • SHORT COMMUNICATION Rocío Sancho, Manuel Medarde, Sonsoles Sánchez-Palomino, Blanca M. Madrigal, José Alcamí, Eduardo Muñoz and Arturo San Feliciano SummaryPlus | Full Text + Links | PDF (264 K) | |||
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Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids • SHORT COMMUNICATION Toh-Seok Kam, Kooi-Mow Sim, Huey-Shen Pang, Takashi Koyano, Masahiko Hayashi and Kanki Komiyama SummaryPlus | Full Text + Links | PDF (266 K) | |||
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A suitable 1,2,4-oxadiazoles synthesis by microwave irradiation • SHORT COMMUNICATION Vincenzo Santagada, Francesco Frecentese, Elisa Perissutti, Donatella Cirillo, Sara Terracciano and Giuseppe Caliendo SummaryPlus | Full Text + Links | PDF (247 K) | |||
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Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics • SHORT COMMUNICATION Todd C. Henninger, Xiaodong Xu, Darren Abbanat, Ellen Z. Baum, Barbara D. Foleno, Jamese J. Hilliard, Karen Bush, Dennis J. Hlasta and Mark J. Macielag SummaryPlus | Full Text + Links | PDF (293 K) | |||
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The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds • SHORT COMMUNICATION Daniel Fernández, Mary Anne Wenck, Sydney P. Craig, III and José M. Delfino SummaryPlus | Full Text + Links | PDF (307 K) | |||
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Isoindolinone ureas: a novel class of KDR kinase inhibitors • SHORT COMMUNICATION Michael L. Curtin, Robin R. Frey, H. Robin Heyman, Kathy A. Sarris, Douglas H. Steinman, James H. Holmes, Peter F. Bousquet, George A. Cunha, Maria D. Moskey, Asma A. Ahmed et al. SummaryPlus | Full Text + Links | PDF (321 K) | |||
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Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase • SHORT COMMUNICATION Deane M. Nason, Steven D. Heck, Mathew S. Bodenstein, John A. Lowe, III , Robert B. Nelson, Dane R. Liston, Charles E. Nolan, Lorraine F. Lanyon, Karen M. Ward and Robert A. Volkmann SummaryPlus | Full Text + Links | PDF (271 K) | |||
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Nonpeptide  v 3 antagonists. Part 10: In vitro and in vivo evaluation of a potent 7-methyl substituted tetrahydro-[1,8]naphthyridine derivative • SHORT COMMUNICATIONMichael J. Breslin, Mark E. Duggan, Wasyl Halczenko, George D. Hartman, Le T. Duong, Carmen Fernandez-Metzler, Michael A. Gentile, Donald B. Kimmel, Chih-Tai Leu, Kara Merkle et al. SummaryPlus | Full Text + Links | PDF (260 K) | |||
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Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity • SHORT COMMUNICATION Dong-Yun Shin, Sun Nam Kim, Jung-Hyun Chae, Soon-Sil Hyun, Seung-Yong Seo, Yong-Sil Lee, Kwang-Ok Lee, Seok-Ho Kim, Yun-Sang Lee, Jae Min Jeong et al. Abstract | PDF (261 K) | |||
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AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey • SHORT COMMUNICATION Robert D. Selliah, Mark R. Hellberg, Najam A. Sharif, Marsha A. McLaughlin, Gary W. Williams, Daniel A. Scott, David Earnest, Karen S. Haggard, W. Dennis Dean, Pete Delgado et al. SummaryPlus | Full Text + Links | PDF (276 K) | |||
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Antibody light chain-catalyzed hydrolysis of a hepatitis C virus peptide • SHORT COMMUNICATION Hiroaki Taguchi, Zhenyong Keck, Steven K. H. Foung, Sudhir Paul and Yasuhiro Nishiyama SummaryPlus | Full Text + Links | PDF (327 K) | |||
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Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides • SHORT COMMUNICATION Yong-Jin Wu, Li-Qiang Sun, Huan He, Jie Chen, John E. Starrett, Jr. , Pierre Dextraze, Jean-Paul Daris, Christopher G. Boissard, Rick L. Pieschl et al. SummaryPlus | Full Text + Links | PDF (322 K) | |||
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Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase • SHORT COMMUNICATION K. Shankaran, Karla L. Donnelly, Shrenik K. Shah, Ravindra N. Guthikonda, Malcolm MacCoss, John L. Humes, Stephen G. Pacholok, Stephan K. Grant, T. M. Kelly and K. K. Wong Abstract | PDF (272 K) | |||
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Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia • SHORT COMMUNICATION Jean Jacques Vanden Eynde, Annie Mayence, Tien L. Huang, Margaret S. Collins, Sandra Rebholz, Peter D. Walzer and Melanie T. Cushion SummaryPlus | Full Text + Links | PDF (263 K) | |||
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Synthesis and neurotrophic activity of nonimmunosuppressant cyclosporin A derivatives • SHORT COMMUNICATION Ling Wei, Joseph P. Steiner, Gregory S. Hamilton and Yong-Qian Wu Abstract | PDF (270 K) | |||
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Design, synthesis, and biochemical evaluation of novel v3 integrin ligands • SHORT COMMUNICATION Juan Jose Marugan, Kristin D. Haslow and Carl Crysler Abstract | PDF (249 K) | |||
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Discovery of new chemical leads for prostaglandin D2 receptor antagonists • SHORT COMMUNICATION Kazuhiko Torisu, Kaoru Kobayashi, Maki Iwahashi, Hiromu Egashira, Yoshihiko Nakai, Yutaka Okada, Fumio Nanbu, Shuichi Ohuchida, Hisao Nakai and Masaaki Toda Abstract | PDF (267 K) | |||
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Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions • SHORT COMMUNICATION Alessio Innocenti, Sabrina Zimmerman, James Ferry, Andrea Scozzafava and Claudiu Supuran SummaryPlus | Full Text + Links | PDF (291 K) | |||
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Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors • SHORT COMMUNICATION Manik R. Pullagurla, Richard B. Westkaemper and Richard A. Glennon SummaryPlus | Full Text + Links | PDF (374 K) | |||
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SAR and pharmacokinetic studies on phenethylamide inhibitors of the hepatitis C virus NS3/NS4A serine protease • SHORT COMMUNICATION Savina Malancona, Stefania Colarusso, Jesus M. Ontoria, Antonella Marchetti, Marco Poma, Ian Stansfield, Ralph Laufer, Annalise Di Marco, Marina Taliani, Maria Verdirame et al. Abstract | PDF (275 K) | |||
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Chemoenzymatic synthesis of (S) and (R)-propranolol and sotalol employing one-pot lipase resolution protocol • SHORT COMMUNICATION Ahmed Kamal, Mahendra Sandbhor and Ahmad Ali Shaik SummaryPlus | Full Text + Links | PDF (258 K) | |||
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Non-peptide oxytocin agonists • SHORT COMMUNICATION Gary Pitt, Andrzej Batt, Robert Haigh, Andrew Penson, Peter Robson, David Rooker, André Tartar, Julie Trim, Christopher Yea and Michael Roe SummaryPlus | Full Text + Links | PDF (298 K) | |||
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Editorial board • EDITORIAL BOARD PDF (398 K) | |||
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Contributors to this issue • INDEX PDF (190 K) | |||
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Instructions to contributors • PUBLISHER'S NOTE PDF (70 K) | |||
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